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Interaction between mercaptopurine and milk

Provincial Systemic Therapy Program, British Columbia Cancer Agency, Canada, mdelemos{at}bccancer.bc.ca

Linda Hamata, BSc Pharm

Provincial Systemic Therapy Program, British Columbia Cancer Agency, Canada

Sarah Jennings, BSc Biomed, BSc Pharm

Provincial Systemic Therapy Program, British Columbia Cancer Agency, Canada

Tanya Leduc, BSP

Provincial Systemic Therapy Program, British Columbia Cancer Agency, Canada

Mercaptopurine is a purine analog used for acute lymphoblatic leukemia and chronic myelogenous leukemias. Since it is inactivated by xanthine oxidase (XO), concurrent intake of substances containing XO may potentially reduce bioavailability of mercaptopurine. Cow's milk is known to contain a high level of XO. In vitro and in vivo data suggest that concurrent intake of cow's milk may reduce the bioavailability of mercaptopurine. This interaction may be clinically significant. Therefore most patients should try to separate the timing of taking mercaptopurine and drinking milk. J Oncol Pharm Practice (2007) 13: 237—240.

Key Words: mercaptopurine • milk • drug interaction • xanthine oxidase

References

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Journal of Oncology Pharmacy Practice, Vol. 13, No. 4, 237-240 (2007)
DOI: 10.1177/1078155207080802


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by de Lemos, M. L. Articles by Leduc, T. Search for Related Content PubMed PubMed Citation Articles by de Lemos, M. L. Articles by Leduc, T. Social Bookmarking                         What's this?