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Journal of Oncology Pharmacy Practice, Vol. 12, No. 3,
179-181 (2006)
DOI: 10.1177/1078155206069165
Development of daptomycin resistance in a bone marrow transplant patient with vancomycin-resistant Enterococcus durans
Myke R Green, PharmD
Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Claudio Anasetti, MD
Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Ramon L Sandin, MD
Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Nancy E Rolfe, ARNP
Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
John N Greene, MD
Department of Interdisciplinary Oncology, University of South Florida, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Daptomycin has demonstrated antibacterial activity against several antibiotic-resistant strains, including vancomycin-resistant enterococci.1 A paucity of data exists concerning in vivo development of daptomycin resistance of enterococci. We describe an allogeneic bone marrow transplant patient, who was found to have vancomycin-resistant Enterococcus durans bacteremia, which subsequently developed resistance to daptomycin.
Key Words: daptomycin resistance vancomycin-resistant enterococci in vivo resistance immuno-compromise
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