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Journal of Oncology Pharmacy Practice, Vol. 12, No. 3, 155-164 (2006)
DOI: 10.1177/1078155206070774

Fatigue in cancer patients treated with cytotoxic drugs

Per Hartvig, PharmD, PhD

Hospital Pharmacy, University Hospital, Uppsala, Sweden

Johan Aulin, MSc in pharmacy

Hospital Pharmacy, University Hospital, Uppsala, Department of Pharmacokinetics and Drug Therapy, Uppsala University, Uppsala, Sweden

Matilda Hugerth, MSc in pharmacy

Department of Pharmacokinetics and Drug Therapy, Uppsala University, Uppsala, Sweden

Sofia Wallenberg, MSc in pharmacy

Department of Pharmacokinetics and Drug Therapy, Uppsala University, Uppsala, Sweden

Gunnar Wagenius, MD, PhD

Department of Oncology, University Hospital, Uppsala, Sweden

Study objectives. Cancer-related fatigue is a significant and distressing problem for the cancer patient, affecting their physical and psychosocial function negatively, and reducing their quality of life. The aims of this study were to assess frequency, severity, and the consequence of fatigue in cancer outpatients receiving cytotoxic drugs, using an existing international fatigue scale applied for Swedish use.

Methods. The study used a non-randomized, prospective design to evaluate fatigue and its impact on quality of life in outpatients receiving cytotoxic drugs. Once a week, 147 cancer patients, in an outpatient ward for cytotoxic drug administration, filled out questionnaires containing 13 items from the Fatigue Symptom Inventory (FSI), and five additional questions.

Results. Prevalence of fatigue was 92% in the week after all patients had received cytotoxic drugs, and patients were statistically significantly more fatigued during than before treatment. The degree of fatigue was highest the week after treatment, and declined over the following week. Other symptoms, especially depressed mood, showed a strong correlation with cancer and cytotoxic-induced fatigue. Lung and breast cancer patients experienced the highest degree of fatigue. Some cytotoxic drug regimens were, apart from the underlying disease, associated with high fatigue scores, eg, those with cyclophosphamide or gemcitabine. Patients not receiving first line treatment scored significantly higher fatigue with more influence on daily living.

Conclusion. The study verified that fatigue is a common side effect, and affects quality of life negatively, even for outpatients receiving cytotoxic drugs. The clinical oncology pharmacist must inform patients that a severe tiredness, fatigue, may follow cytotoxic drug administration.

Key Words: cytotoxic drugs • fatigue • quality of life • self-report • side effects

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