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Journal of Oncology Pharmacy Practice
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Extravasation of topotecan, a report of two cases

Lonneke MM Oostweegel

Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands

Laurence JC van Warmerdam

Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands

Margaret Schot

Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands

Ria C Dubbelman

Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands

Wim W Ten Bokkel Huinink

Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands

Jos H Beijnen

Division of Medical Oncology, Antoni van Leeuwenhoek Hospital, Netherlands Cancer Institute, Amsterdam, The Netherlands

Objective. Extravasations of anticancer agents may give serious complications and specific therapy might be needed. Topotecan is a new cytotoxic drug and is used in many clinical studies. In our clinic two extravasations of topotecan occurred, and the clinical consequences are discussed.

Clinical Features. The extravasations oc curred in two patients who were receiving topo tecan intravenously because of ovarian carcinoma stage III. The patients experienced some discom fort caused by the expansion of soft tissue. How ever, no serious complications were observed.

Case Progress and Outcome. Both patients received all further courses of topotecan without any negative effects.

Conclusion. In conclusion, besides stopping the injection, trying to aspirate the fluid, keeping the arm high, and cooling the swelling, we advise no specific measures to be taken after extravasa tion of topotecan.

Key Words: Topotecan • extravasation; adverse effects.

Journal of Oncology Pharmacy Practice, Vol. 3, No. 2, 115-116 (1997)
DOI: 10.1177/107815529700300205
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