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Chemical stability of cyclophosphamide, trofosfamide, and 2- and 3-dechloroethylifosfamide in aqueous solutions

Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, Utrecht

T. Aalbers

Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, Utrecht

J.H. Beijnen

Slotervaart Hospital/Netherlands Cancer Institute, Amsterdam, The Netherlands

A. Bult

Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, Utrecht

W.J.M. Underberg

Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, Utrecht

The degradation kinetics of various oxazaphospho rines : trofosfamide, cyclophosphamide, and 2- and 3-dechloroethylifosfamide was studied by means of a high-performance liquid chromatographic method. The results were compared with the kinetics of ifosfamide. It appeared that the pres ence and the site of the chloroethyl group influ enced the chemical stability of the compounds.

Key Words: Stability • cyclophosphamide; trofosfamide • dechloroethylated metabolites.

Journal of Oncology Pharmacy Practice, Vol. 2, No. 1, 15-21 (1996)
DOI: 10.1177/107815529600200102


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