SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Oncology Pharmacy Practice
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Roberts, S.
Right arrow Articles by Sewell, G. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roberts, S.
Right arrow Articles by Sewell, G. J
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Studies on the decontamination of surfaces exposed to cytotoxic drugs in chemotherapy workstations

Sarah Roberts, Bsc

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK

Nancy Khammo, PhD

Steris Ltd, Basingstoke, Hampshire, UK

Gerald McDonnell, PhD

Steris Ltd, Basingstoke, Hampshire, UK

Graham J Sewell, PhD, BPharm

Department of Pharmacy, Kingston University, Kingston-Upon-Thames, Surrey, UK

Objective. The aim of this study was to examine the removal and deactivation of cytotoxic contamination from surfaces of a pharmaceutical isolator workstation.

Methods. Three marker cytotoxic drugs were evaluated in three phases using decontamination technologies currently available in the pharmaceutical and healthcare environments. Phase I investigated the physical removal of contamination by detergents. Phase II and III investigated the effectiveness of detergents and Vaporised Hydrogen Peroxide (VHP®) in degrading cytotoxic drugs, respectively.

Results. 5-Flurouracil, doxorubicin and cyclophosphamide were removed from a surface by wiping with detergents. VHP® and alkaline detergents caused degradation of doxorubicin. The observed effect with detergent cleaning was pH dependent, but neither of the technologies applied had any effect on the chemical stability of 5-flurouracil and cyclophosphamide under the conditions tested.

Key Words: cyclophosphamide • cytotoxic • decontamination • degradation • doxorubicin • 5-flurouracil • vaporized hydrogen peroxide

Journal of Oncology Pharmacy Practice, Vol. 12, No. 2, 95-104 (2006)
DOI: 10.1177/1078155206070439
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 ANN OCCUP HYGHome page
K. Touzin, J.-F. Bussieres, E. Langlois, M. Lefebvre, and C. Gallant
Cyclophosphamide Contamination Observed on the External Surfaces of Drug Vials and the Efficacy of Cleaning on Vial Contamination
Ann. Hyg., November 1, 2008; 52(8): 765 - 771.
[Abstract] [Full Text] [PDF]


Advertisement