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Journal of Oncology Pharmacy Practice
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Management of extravasation of oxaliplatin

Mário L de Lemos, MSc (Clin Pharm), PharmD, MSc (Oncology) candidate

British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada

Susan Walisser, BSc (Pharm)

British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada

Oxaliplatin extravasation has been associated with local pain and inflammation which may be severe and lead to complications including necrosis. Recent case reports suggest that oxaliplatin may be better classified as an irritant when extrava-sated. The optimal management of oxaliplatin extravasation however remains uncertain. Cold compress may cause local vasoconstriction and reduce cellular injury. However, it may potentially precipitate or worsen peripheral neuropathy. Warm compress may increase drug removal by local vasodilation and avoid peripheral neuropathy. However, it may potentially increase cellular uptake and hence injury. Further research into this area is needed.

Key Words: extravasation • oxaliplatin • platinum

Journal of Oncology Pharmacy Practice, Vol. 11, No. 4, 159-160 (2005)
DOI: 10.1191/1078155205jp165oa
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