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Journal of Oncology Pharmacy Practice
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Leaching of diethylhexyl phthalate from polyvinyl chloride materials into etoposide intravenous solutions

Mário L de Lemos, MSc (Clin Pharm), PharmD

British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada

Linda Hamata, BSc (Pharm)

British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada

Thanh Vu, BSc (Pharm), PharmD

British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada

Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etopo-side bags and tubings made from non-PVC materials.

Key Words: diethylhexyl phthalate • drug incompatibility • etoposide • polyvinyl chloride

Journal of Oncology Pharmacy Practice, Vol. 11, No. 4, 155-157 (2005)
DOI: 10.1191/1078155205jp164oa
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