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Journal of Oncology Pharmacy Practice
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Erythropoietin and neuroprotection: a therapeutic perspective

M. Milano, PharmD

Centre de convalescence du CHU de Nice, Tende, France

R. Collomp, PharmD

Hôpital de l’archet Service Pharmacie, 151, route Saint Antoine de ginestiére, 06200 Nice, France

Recombinant erythropoietin (EPO) is used to correct for anaemia caused by chronic renal failure or cancer therapy. Improvement of the quality of life of anaemic patients treated with EPO was recently demonstrated and preliminary clinical results suggest an improvement of cognitive functions in patients receiving EPO. High expression of EPO and its receptor in the brain during embryonic development has led to the investigation of not only the neurotrophic role of EPO but also its neuroprotective properties. The neuroprotective effects of EPO have various complementary actions including antagonism of the effects of glutamate, increased expression of antioxidant enzymes, changes in production of neurotransmitters and induction of neuroglobin. Convincing experimental results suggest a blood-brain transport of EPO whereas clinical pharmacokinetic data do not as yet support this. The neuroprotective effects of EPO and its therapeutic promise need to be underlined.

Key Words: central nervous system • cognitive function • erythropoietin • neuroprotection • quality of life

Journal of Oncology Pharmacy Practice, Vol. 11, No. 4, 145-149 (2005)
DOI: 10.1191/1078155205jp162oa
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