This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Dorr, R. T. Articles by Liddil, J. D. Search for Related Content PubMed Articles by Dorr, R. T. Articles by Liddil, J. D. Social Bookmarking                         What's this?

Stability of mitomycin C in different infusion fluids: Compatibility with heparin and glucocorticosteroids

College of Pharmacology, University of Arizona, Arizona Cancer Center, 1515 N. Campbell Avenue, Tucson, AZ, USA

James D. Liddil, MS

College of Pharmacology, University of Arizona, Arizona Cancer Center, 1515 N. Campbell Avenue, Tucson, AZ, USA

Introduction: Mitomycin C (Mutamycin) stability and compatibility was analyzed by reverse-phase high performance liquid chromatography (HPLC).

Methods: The drug was reconstituted in sterile water for injection USP, 0.9% sodium chloride for injection USP, 5% dextrose injection USP and lactated Ringer's injection USP. Samples were stored for vari ous times at —20°C, 4°C and 25°C in both glass and plastic (polyvinyl chloride) containers.

Results: Mitomycin C was shown to be stable (> 90% remaining for 5 to 7 days at room temperature in nondextrose containing infusion fluids. Greater stability was noted at drug concentrations 0.4 µg/mL and at reduced temperatures. In 5% dextrose solutions, stability was highly dependent upon pH: 3.4 hours at pH 4.7 and slightly over 24 hours at pH 5.5. Non-linear decomposition in dextrose was due to a slow increase in solution pH after adding mitomycin C. There were no stability differences for glass or plastic containers. Mitomycin was shown to be stable for prolonged periods when mixed with dexametha sone sodium phosphate (T ₉₀% > 2 days), with hydro cortisone sodium succinate (T₉₀% > 7 days) or with sodium heparin (T ₉₀% > 2 days). Within these times, the concentrations of corticosteroids (measured by HPLC) and heparin (measured by bioassay) did not significantly decline.

Conclusions: Mitomycin C demonstrates pro longed stability in nonacidic infusion fluids. Long- term storage in dextrose-containing solutions should be avoided, but short-term admixture with heparin and corticosteroids is feasible.

Journal of Oncology Pharmacy Practice, Vol. 1, No. 3, 19-24 (1995)
DOI: 10.1177/107815529500100304


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?