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Cytogenetic monitoring of pharmaceutical staff working with cytostatic drug preparations: A 5-year follow-up

Dienst der Freien und Hansestadt Hamburg, Alter Steinweg 4, D-20459 Hamburg

Sibylle Nagel

Dienst der Freien und Hansestadt Hamburg, Alter Steinweg 4, D-20459 Hamburg

Frank Haamann

Dienst der Freien und Hansestadt Hamburg, Alter Steinweg 4, D-20459 Hamburg

Simone Melzer

Allg. Krankenhauses Harburg, Eissendorfer Pferdeweg 52, D-21075 Hamburg, Germany

Klaus Meier

Allg. Krankenhauses Harburg, Eissendorfer Pferdeweg 52, D-21075 Hamburg, Germany

Introduction. Cytostatic drug preparation in hos pital pharmacies leads to a concentration of expo sure on a few people and requires considerable protective measures.

Methods. To prove the efficiency of those standards, 45 people who routinely prepare cyto static drugs were monitored with cytogenetic tests, Micronucleus-rate (MN), and Sister Chroma tid Exchange-rate (SCE), once a year over a period up to 5 years. All participants of the study received a physical examination before they began prepar ing cytostatic drugs. Baseline MN and SCE were performed at the time. Individual comparisons for the tests between pre- and post-exposure, and a comparison between an exposed and an unex posed group were then performed.

Results. During the 5-year follow-up there were no hints of genotoxic effects as a result of handling cytostatic drugs.

Conclusion. Thus, it appeared that the safety precautions employed at this Institute were ade quate.

Key Words: Sister chromatid exchanges (SCE) • micronucleus (MN) • cytostatic drugs; cytogenetic monitoring • pharmaceutical staff.

Journal of Oncology Pharmacy Practice, Vol. 1, No. 1, 33-39 (1995)
DOI: 10.1177/107815529500100104


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